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    As noted at the end of the 19th century by a German writer promoting careful
    statistical evaluation of treatments in general, “to substantiate the efficacy of…
    quinine in malaria, one may not need statistics” (Ephraim 1890-94). By contrast, it
    was not possible to make similarly confident causal inferences about the effects
    of most  The effectiveness of the quinine treatment may be considerably lower because of
    discontinuation of treatment due to early discharge, the occurrence of side effects
    or because of the fact that patients feel better and stop the treatment. Therefore,
    sulfadoxine-pyrimethamine (SP) is often added at discharge. This regimen has 
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    Severe malaria kills more than a half million people each year. Based on high-
    quality evidence of the efficacy superiority of artesunate over quinine in adults
    and children with severe malaria, the World Health Organization guidelines have
    been revised. The WHO currently recommends injectable artesunate as the first-
    line 
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    Quinine, an old anti-malarial drug in a modern world: role in the treatment of
    malaria. Jane AchanEmail author,; Ambrose O Talisuna,; Annette Erhart,; Adoke
    Yeka,; James K Tibenderana,; Frederick N Baliraine,; Philip J Rosenthal and;
    Umberto D’Alessandro. Malaria Journal201110:144.
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    Delay in treatment of P falciparum malaria can lead to the development or
    worsening of severe malaria, which has a poorer prognosis than uncomplicated
    malaria. Chloroquine, quinine, quinidine, halofantrine, and artemisinin
    compounds are the rapidly acting drugs that can terminate an acute malaria …
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    The effectiveness of the quinine treatment may be considerably lower because of
    discontinuation of treatment due to early discharge, the occurrence of side effects
    or because of the fact that patients feel better and stop the treatment. Therefore,
    sulfadoxine-pyrimethamine (SP) is often added at discharge. This regimen has 
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    Disclaimer: This information should not be used to decide whether or not to take
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    Although blurred vision from quinine toxicity is well documented in literature, an
    acute effect leading to blindness is infrequently reported. We report a case of
    sudden bilateral blindness in a child after quinine treatment for severe malaria.
    Ocular examination revealed no acute pathology except widely dilated non-
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    As noted at the end of the 19th century by a German writer promoting careful
    statistical evaluation of treatments in general, “to substantiate the efficacy of…
    quinine in malaria, one may not need statistics” (Ephraim 1890-94). By contrast, it
    was not possible to make similarly confident causal inferences about the effects
    of most 
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